IT2033 BIO INFORMATICS L T P C

IT2033 BIO INFORMATICS L T P C
3 0 0 3
UNIT I 9
Introduction to molecular biology – the genetic material – gene structure – protein
structure – chemical bonds – molecular biology tools – genomic information content
UNIT II 9
Data searches – simple alignments – gaps – scoring matrices – dynamic programming –
global and local alignments – database searches – multiple sequence alignments
Patterns for substitutions – estimating substitution numbers – evolutionary rates –
molecular clocks – evolution in organelles
UNIT III 9
Phylogenetics – history and advantages – phylogenetic trees – distance matrix methods
– maximum likelihood approaches – multiple sequence alignments – Parsimony –
ancestral sequences – strategies for faster searches – consensus trees – tree
confidence – comparison of phylogenetic methods – molecular phylogenies
UNIT IV 9
Genomics – prokaryotic genomes: prokaryotic gene structure – GC content - gene
density – eukaryotic genomes: gene structure – open reading frames – GC content –
gene expression – transposition – repeated elements – gene density
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UNIT V 9
Amino acids – polypeptide composition – secondary structure – tertiary and quaternary
structure – algorithms for modeling protein folding – structure prediction – predicting
RNA secondary structures
Proteomics – protein classification – experimental techniques – inhibitors and drug
design – ligand screening – NMR structures – empirical methods and prediction
techniques – post-translational modification prediction
TOTAL: 45 PERIODS
TEXT BOOK:
1. D. E. Krane and M. L. Raymer, “Fundamental concepts of Bioinformatics”, Pearson
Education, 2003.
REFERENCES:
1. Arthur M. Lesk, “Introduction to Bioinformatics”, Second Edition, Oxford University
Press, 2005.
2. T. K. Attwood, D. J. Parry-Smith, and S. Phukan, “Introduction to Bioinformatics”,
Pearson Education, 1999.
3. Vittal R. Srinivas, “Bioinformatics – A Modern Approach”, Prentice-Hall of India Pvt.
Ltd., 2005.